Genomic Insights into Intrinsic and Acquired Drug Resistance Mechanisms in Achromobacter xylosoxidans
نویسندگان
چکیده
منابع مشابه
New Insights in to the Intrinsic and Acquired Drug Resistance Mechanisms in Mycobacteria
Infectious diseases caused by clinically important Mycobacteria continue to be an important public health problem worldwide primarily due to emergence of drug resistance crisis. In recent years, the control of tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (MTB), is hampered by the emergence of multidrug resistance (MDR), defined as resistance to at least isoniazid (INH) an...
متن کاملIntrinsic and acquired resistance mechanisms in enterococcus
Enterococci have the potential for resistance to virtually all clinically useful antibiotics. Their emergence as important nosocomial pathogens has coincided with increased expression of antimicrobial resistance by members of the genus. The mechanisms underlying antibiotic resistance in enterococci may be intrinsic to the species or acquired through mutation of intrinsic genes or horizontal exc...
متن کاملMechanisms and insights into drug resistance in cancer
Cancer drug resistance continues to be a major impediment in medical oncology. Clinically, resistance can arise prior to or as a result of cancer therapy. In this review, we discuss different mechanisms adapted by cancerous cells to resist treatment, including alteration in drug transport and metabolism, mutation and amplification of drug targets, as well as genetic rewiring which can lead to i...
متن کاملAchromobacter xylosoxidans: a rare pathogen for community-acquired acute pancreatitis
Achromobacter, an aerobic, non-fermentative, Gram-negative rod is rarely isolated from clinical material. It can be confused with Pseudomonas spp. in clinical specimens, so that its role as a significant pathogen is underestimated. This organism was first described and named by Yabuuchi in 1971. (Yabuuchi & Oyama, 1971). Seven species are currently described within the genus Achromobacter, name...
متن کاملMechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria
Polymyxins are polycationic antimicrobial peptides that are currently the last-resort antibiotics for the treatment of multidrug-resistant, Gram-negative bacterial infections. The reintroduction of polymyxins for antimicrobial therapy has been followed by an increase in reports of resistance among Gram-negative bacteria. Some bacteria, such as Klebsiella pneumoniae, Pseudomonas aeruginosa, and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2014
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.04260-14